Mistletoe Therapy
Mistletoe is one of the most widely studied complementary and alternative medicine therapies for cancer.
In certain European countries, extracts made from European mistletoe are among the most prescribed therapies for cancer patients.
Mistletoe Therapy In Virginia
Mistletoe Therapy is currently in clinical trials at Johns Hopkins Sidney Kimmel Cancer Center in Baltimore, Md.

Turn on the Immune System
Mistletoe, a plant that grows in trees, has been used since the 1800s in Germany to treat cancer. The plant has been studied extensively by the German government documenting its mechanisms of actions and active chemical constituents with hundreds of clinical and basic research studies.
The European trials suggest that mistletoe therapy may be providing benefits to cancer patients such as reduction of chemotherapy and radiation sides effects (lack of appetite, nausea, vomiting, etc.), and can lower the pain from tumors. The quality of life of these patients seems to have been significantly improved.
Currently, both Canada and Germany cover all costs of Mistletoe Therapy as a treatment for cancer including breast, ovarian, colorectal, prostate, pancreatic, kidney cancers and lymphoma/leukemia.
Virginia Integrative Practice offers Mistletoe Therapy in Burke and Charlottesville, Va.
Mistletoe Therapy is a Popular Alternative Medicine
Mistletoe Therapy is currently in clinical trials at Johns Hopkins Sidney Kimmel Cancer Center in Baltimore, Md.
It has been proven in European studies to turn on the immune system activating mechanisms to destroy cancer cells, as well as repair DNA. It can be used in conjunction with chemotherapy and radiation or can be used for palliative care, lengthening survival rates and improving quality of life. It can also be used when cancer goes into remission to prevent a recurrence.
Mistletoe, a plant that grows in trees, has been used since the 1800s in Germany to treat cancer. The plant has been studied extensively by the German government documenting its mechanisms of actions and active chemical constituents with hundreds of clinical and basic research studies.
The European trials suggest that mistletoe therapy may be providing benefits to cancer patients such as reduction of chemotherapy and radiation sides effects (lack of appetite, nausea, vomiting, etc.), and can lower the pain from tumors. The quality of life of these patients seems to have been significantly improved.
Currently, both Canada and Germany cover all costs of Mistletoe Therapy as a treatment for cancer including breast, ovarian, colorectal, prostate, pancreatic, kidney cancers and lymphoma/leukemia. – Dr. Valinda Riggins-Nwadike, MD, MPH, OB-GYN
What is Mistletoe?
This summary discusses research done mainly with the European mistletoe species.
The chemical makeup of mistletoe products varies, depending on many factors, including:
- The type of host tree on which the mistletoe plant grows.
- The time of year the plant is harvested.
- The exact species of mistletoe.
- Whether the extract is fermented or unfermented.
- Whether the extract is prepared with homeopathic methods.
- The company that makes the product.
Mistletoe extracts are prepared as water-based solutions or solutions of water and alcohol. Mistletoe products may be named according to the type of host tree on which the plant grows. For example, IscadorM is from apple trees, IscadorP comes from pine trees, IscadorQu is from oak trees, and IscadorU comes from elm trees. Some users believe that the type of mistletoe extract chosen should depend on the type of tumor and the sex of the patient.
History of Mistletoe Therapy
Extracts of mistletoe have been shown to kill cancer cells in the laboratory and to boost the immune system (the complex group of organs and cells that defends the body against infection or disease). For this reason, mistletoe has been classified as a type of biological response modifier (a substance that stimulates the body’s response to infection and disease). Extracts of mistletoe have also been shown in the laboratory to prevent the growth of new blood vessels needed for tumors to grow.
Ingredients in mistletoe that have been studied for their usefulness in treating cancer include:
- Alkaloids.
- Viscotoxins.
- Polysaccharides.
- Lectins.
Mistletoe Therapy FAQs

blank
What Preclinical (Laboratory or Animal) Studies Have Been Conducted Using Mistletoe?
Studies testing mistletoe’s ability to stop cancer cell growth in animals have yielded mixed and inconsistent results, depending on the extract used, the dose tested, the way it was given, and the type of cancer studied. Results of a few animal studies have suggested that mistletoe may be useful in decreasing the side effects of standard anticancer therapy, such as chemotherapy and radiation therapy, and that it counteracts the effects of drugs used to suppress the immune system, such as cortisone.
Have Any Clinical Trials (Research Studies with People) Been Conducted Using Mistletoe?
Many studies involve using mistletoe as adjuvant therapy in patients with cancer. One retrospective cohort study done in Europe between 1993 and 2000 looked at the use of a mistletoe extract (Iscador) as long-term adjuvant therapy in 800 patients treated with chemotherapy and/or radiation therapy for colorectal cancer that had not spread. The study found that patients treated with Iscador had fewer adverse events, better symptom relief, and improved disease-free survival compared to patients who did not receive Iscador as adjuvant therapy.
A European study published in 2013 looked at the use of Iscador Qu in advanced or metastatic pancreatic cancer. Patients received best supportive care and were randomly assigned to receive either Iscador Qu or no anticancer therapy. Results in 220 patients showed that those treated with Iscador had improved survival and less severe disease-related symptoms (including pain, weight loss, fatigue, nausea, diarrhea, and anxiety) compared with those who did not receive Iscador Qu.
A European study done between 1978 and 1987 looked at the use of Iscador U and Iscador Qu in non-small cell lung cancer that could not be treated with surgery. Patients were randomly assigned to receive one of 3 treatments: (1) Iscador injections; (2) Polyerga Neu injections (a sheep spleen preparation said to stimulate the immune system and have anti-tumor effects); or (3) placebo injections of a vitamin B mixture. Results in 312 patients showed no differences between the 3 groups in survival or tumor response. It was noted that more patients in the Iscador group reported an improved sense of well-being compared with patients in the other groups.
Before researchers can conduct clinical drug research in the United States, they must file an Investigational New Drug (IND) application with the Food and Drug Administration (FDA). The FDA does not make information public about IND applications or approvals; this information can be made public only by the applicants. In the last decade, at least two U.S. investigators were given approval to conduct clinical trials of mistletoe as a treatment for people with cancer. These clinical trials are now closed.
In 2002, the National Center for Complementary and Integrative Health (NCCIH), in cooperation with the National Cancer Institute (NCI), began enrolling patients for a phase I clinical trial of a mistletoe extract (Helixor A) and gemcitabine in patients with advanced solid tumors. This combination showed low toxicity and no botanical -drug interactions were reported.
How is Mistletoe Therapy Useful in Treating Cancer?
- Have effects on the immune system.
- Kill mouse, rat, and human cancer cells in the laboratory.
- Protect the DNA in white blood cells in the laboratory, including cells that have been exposed to DNA-damaging chemotherapy drugs.
Is Mistletoe Therapy Clinically Reviewed?
- Quality of life was measured in a review that included 26 randomized clinical trials. Of these, 22 trials showed patients had improved quality of life. All 10 non-randomized, controlled clinical trials reviewed also reported the same benefits. Chemotherapy-related fatigue, nausea and vomiting, depression, emotional well-being, and concentration improved. Some of the studies were well designed, while others had weaknesses.
- Tumor response, quality of life, and psychological distress were measured in a review of 21 randomized clinical trials in patients with different types of cancer. A variety of mistletoe extracts were used either alone, with chemotherapy, or with radiation therapy. Most of the studies reported benefits for patients, although this review had weaknesses in design and size.
- Quality of life and survival were measured in a review of 10 randomized clinical trials which used a variety of mistletoe extracts in patients with different types of cancer. There was no difference in survival or quality of life measures in patients who received mistletoe compared to those who did not.
Have Any Side Effects or Risks Been Reported from Mistletoe?
How Is Mistletoe Therapy Administered?
Interested in the benefits of mistletoe therapy for you?
Call for an appointment today! Evening and weekend hours are available.
Integrative Medicine and Holistic Medicine Services